2-氨基甲酰基-3-硝基苯甲酸合成路线 （共 22 条）
反应条件
1: With potassium hydroxide; water T=0 - 30°C; 6 h; 2: With hydrogenchloride; water T=0°C; 1 h;
参考文献
Muller, George; Man, Hon-Wah; Cohen, Benjamin M.; Li, Ying; Xu, Jean; Leong, William W.
Patent: US2012/232100 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
ammonia; water T=80°C;
参考文献
GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; ENGELS, Michael; GERMANN, Tieno; DE VRY, Jean; JOSTOCK, Ruth; HEES, Sabine
Patent: WO2010/142402 A1, 2010 ;
Location in patent: Page/Page column 109 ;
参考文献
Journal of the Chemical Society, , vol. 127, p. 1794
反应条件
1: 93 percent / Br2; aq. KOH / 3 h / 60 °C 2: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr 3: 77 percent / 4 M HCl / 1 h / Heating View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: 93 percent / Br2; aq. KOH / 3 h / 60 °C 2: SOCl2 / tetrahydrofuran; dimethylformamide / 20 °C 3: conc. aq. NH3 / tetrahydrofuran; dimethylformamide View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: With potassium hydroxide; bromine in water T=-10 - 65°C; 1.41667 h; 2: With hydrogenchloride in water T=50 - 55°C;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2007/6566 A1, 2007 ;
Location in patent: Page/Page column 28; 33 ;
WO 2007/006566 A1
反应条件
1: With potassium hydroxide; bromine in water T=0 - 100°C; 1.58333 h; 2: With hydrogenchloride; water T=0°C; 1 h;
参考文献
Muller, George; Man, Hon-Wah; Cohen, Benjamin M.; Li, Ying; Xu, Jean; Leong, William W.
Patent: US2012/232100 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 93 percent / Br2; aq. KOH / 3 h / 60 °C 2: 66 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr 3: 72 percent / 4 M HCl / 1 h / Heating View Scheme
参考文献
White; Almassy; Calvert; Curtin; Griffin; Hostomsky; Maegley; Newell; Srinivasan; Golding
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4084 - 4097
反应条件
1: aq. KOH; Br2 / 80 °C 2: NaOH; hydrazine hydrate; Raney Ni View Scheme
参考文献
Moyer; Weber; Gross
Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4595 - 4601
参考文献
Organic Process Research and Development, , vol. 11, # 4 p. 693 - 698
