1-O-十六烷基-2-乙酰基-外消旋-甘油-3-磷酰胆碱合成路线 （共 13 条）
反应条件
1: 45 percent / tris*HCl buffer (pH=8.14)aq., CaCl2 / 1 h / Ambient temperature; bee venom phospholipase A2 2: 96 percent / pyridine / 8 h / 50 °C View Scheme
参考文献
Pharmazie, , vol. 41, # 8 p. 596 - 596
反应条件
1: 1.) POCl3, Et3N, 2.) pyridine / 1.) CHCl3, 60-65 deg C, 30 min, 2.) CHCl3, RT, 5 h
2: 99 percent / H2 / 10percent Pd/C / methanol / 3 h / 1551.4 Torr / Ambient temperature
3: 89 percent / DMAP
View Scheme
参考文献
Surles; Wykle; O'Flaherty; Salzer; Thomas; Snyder; Piantadosi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 73 - 78
反应条件
1: 99 percent / H2 / 10percent Pd/C / methanol / 3 h / 1551.4 Torr / Ambient temperature
2: 89 percent / DMAP
View Scheme
参考文献
Surles; Wykle; O'Flaherty; Salzer; Thomas; Snyder; Piantadosi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 73 - 78
反应条件
pyridine
T=40°C; 8 h;
参考文献
Kertscher
Pharmazie, 1983 , vol. 38, # 6 p. 421 - 422
反应条件
1: 92 percent / Et3N / toluene / 2 h
2: 95 percent / Et3N / toluene / 3 h / -10 - 20 °C
3: 52 percent / ammonium bifluoride / methanol / 3 h
4: Et3N / toluene / 3 h / Ambient temperature
5: toluene / 48 h / 60 - 70 °C
View Scheme
参考文献
Kruglyak, Yu. L.; Malekin, S. I.; Bykovskaya, S. N.; Dobryanskii, V. S.; Kiselevskii, M. V.; et al.
Pharmaceutical Chemistry Journal, 1993 , vol. 27, # 7 p. 483 - 486
Khimiko-Farmatsevticheskii Zhurnal, 1993 , vol. 27, # 7 p. 24 - 27
反应条件
1: NaH / dimethylformamide
2: B(OH)3, (EtO)3B / Heating
3: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
4: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
5: H2 / 10percent Pd/C / ethanol / 12 h / 40 °C / 1034.3 Torr
6: Et3N / CHCl3 / 24 h / Heating
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
1: B(OH)3, (EtO)3B / Heating
2: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
3: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
4: H2 / 10percent Pd/C / ethanol / 12 h / 40 °C / 1034.3 Torr
5: Et3N / CHCl3 / 24 h / Heating
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
1: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
2: H2 / 10percent Pd/C / ethanol / 12 h / 40 °C / 1034.3 Torr
3: Et3N / CHCl3 / 24 h / Heating
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
反应条件
1: K2CO3 / methanol / 4 h / Ambient temperature
2: Et3N / trichloroethene / 4 h
3: 1M Na2CO3
4: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C
5: H2 / Pd/C / ethanol / 5 h / 50 °C
6: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
反应条件
1: 1M Na2CO3
2: CHCl3; dimethylformamide; propan-2-ol; H2O / 12 h / 50 °C
3: H2 / Pd/C / ethanol / 5 h / 50 °C
4: Et3N / CHCl3
View Scheme
参考文献
Marx; Wiley
Tetrahedron Letters, 1985 , vol. 26, # 11 p. 1379 - 1380
