2-异丙基-3,4-二甲氧基苯甲醛合成路线 （共 12 条）
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=20°C; Condensation; 6 h; 2: With sodium acetate in acetic anhydride; acetic acid Cyclization; 4 h; reflux;
参考文献
Meyers; Willemsen, Jeffrey J.
Tetrahedron, 1998 , vol. 54, # 35 p. 10493 - 10511
反应条件
sodium hydride; benzene Erhitzen des erhaltenen Esters mit Acetanhydrid und Natriumacetat und Erwaermen des Reaktionsprodukts mit wss.-methanol. NaOH;
参考文献
Ognyanov; Petrov; Tiholov; Mollov
Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 353 - 360
反应条件
1: t-BuOK 2: AcONa / acetic acid 3: NaOH / methanol View Scheme
参考文献
Meyers; Willemsen, Jeffrey J.
Tetrahedron Letters, 1996 , vol. 37, # 6 p. 791 - 792
反应条件
1: With methyl trifluoromethanesulfonate in dichloromethane
T=20°C; Ring cleavage; 2 h;
2: With sodium tetrahydroborate in tetrahydrofuran; methanol; dichloromethane
T=0°C; Reduction; 1 h;
参考文献
Meyers; Willemsen, Jeffrey J.
Tetrahedron, 1998 , vol. 54, # 35 p. 10493 - 10511
反应条件
ethylmagnesium bromide in tetrahydrofuran
参考文献
Venuti, Michael C.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3124 - 3127
反应条件
hydrogenchloride; aluminium trichloride; benzene
参考文献
Edwards; Cashaw
Journal of the American Chemical Society, 1956 , vol. 78, p. 3821,3824
反应条件
1.1: (COCl)2; DMF / CH2Cl2 / 4 h / 20 °C
1.2: 96 percent / thionyl chloride / CH2Cl2 / 12 h / 20 °C
2.1: 96 percent / 4 h / reflux
3.1: Methyl trifluoromethane sulfonate / CH2Cl2 / 2 h / 20 °C
3.2: 82 percent / NaBH4 / CH2Cl2; tetrahydrofuran; methanol / 1 h / 0 °C
View Scheme
参考文献
Meyers; Willemsen, Jeffrey J.
Tetrahedron, 1998 , vol. 54, # 35 p. 10493 - 10511
反应条件
1: 84 percent / K2CO3 / acetone / 45 h / Heating
2: 94 percent / Br2 / CCl4 / 0 °C
3: 1.) EtBr, Mg / 1.) THF, reflux, 2.) 0 deg C
View Scheme
参考文献
Ognyanov; Petrov; Tiholov; Mollov
Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 353 - 360
反应条件
unter Einleiten von HCl und anschliessendes Behandeln mit wss. HCl;
参考文献
Edwards; Cashaw
Journal of the American Chemical Society, 1956 , vol. 78, p. 3821,3824
反应条件
2: H2 / 10percentPd-C / acetic acid; aq. HClO4 / 4 h / 60 °C / 2585.7 Torr
3: PPE / CH2Cl2 / 0.5 h / Heating
4: 1.) H2SO4, 2.) o-chloranil / 1.) toluene, reflux, 2h, 2.) reflux, 1h
5: 96 percent / NaBH4 / 1,2-dimethoxy-ethane / 3 h / Heating
6: 95 percent / 150 - 215 °C
7: 87 percent / KOH / acetone / Ambient temperature
View Scheme
参考文献
Venuti, Michael C.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3124 - 3127
