2,3-二氢-1H-吡咯并[1,2-A]苯并咪唑合成路线 （共 35 条）
反应条件
1: With diisobutylaluminium hydride in toluene T=0°C; 23 h; Inert atmosphereReflux; 2: With water; NAF in toluene; benzene T=0 - 20°C; 0.333333 h; Inert atmosphere; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 55, # 1 p. 279 - 281
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in acetonitrile
T=80°C; 1 h; Inert atmosphere;
参考文献
Liubchak, Kostiantyn; Nazarenko, Kostiantyn; Tolmachev, Andrey
Tetrahedron, 2012 , vol. 68, # 14 p. 2993 - 3000
反应条件
[RhCl(cis-cyclooctene)2]2; tri-cyclo-hexyl-phosphine in toluene
T=180°C; 20 h;
参考文献
Tan; Bergman; Ellman
Journal of the American Chemical Society, 2001 , vol. 123, # 11 p. 2685 - 2686
反应条件
1: With caesium carbonate; palladium (II) trifluoroacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene
T=80°C; 18 h;
2: With iron; acetic acid in toluene
0.5 h; Heating / reflux;
3: With sodium hydrogencarbonate in water
Product distribution / selectivity;
参考文献
SANOFI AVENTIS
Patent: WO2009/412 A1, 2008 ;
Location in patent: Page/Page column 33 ;
反应条件
hydrogen; dirhodium tetraacetate; triphenylphosphine in ethyl acetate
T=70°C; P=20685.9 Torr; 20 h;
参考文献
Anastasiou, Despina; Campi, Eva M.; Chaouk, Hassan; Jackson, W. Roy
Tetrahedron, 1992 , vol. 48, # 36 p. 7467 - 7478
反应条件
sodium hydride in tetrahydrofuran; mineral oil
Inert atmosphereReflux;
参考文献
Bastug, Gulluzar; Eviolitte, Christophe; Marko, Istvan E.
Organic Letters, 2012 , vol. 14, # 13 p. 3502 - 3505
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene
5 h; Heating;
参考文献
Aldabbagh, Fawaz; Bowman, W. Russell
Tetrahedron Letters, 1997 , vol. 38, # 21 p. 3793 - 3794
反应条件
PIDA; caesium carbonate in 2,2,2-trifluoroethanol
T=25°C; 2 h;
参考文献
Huang, Jinbo; He, Yimiao; Wang, Yong; Zhu, Qiang
Chemistry - A European Journal, 2012 , vol. 18, # 44 p. 13964 - 13967
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane
T=-30°C; 2 h;
参考文献
Caroon, Joan M.; Fisher, Lawrence E.
Heterocycles, 1991 , vol. 32, # 3 p. 459 - 467
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C; Cyclization; Dehydrobromination; 3.5 h;
参考文献
McClure, James R.; Custer, John H.; Schwarz, H. Dean; Lill, Deborah A.
Synlett, 2000 , # 5 p. 710 - 712
