sulfuric acid in 1,4-dioxane 60 h; Ambient temperature;

sodium hydrogencarbonate in 1,4-dioxane; diethyl ether

sulfuric acid in diethyl ether; chloroform T=20°C; 4 h;

sodium hydroxide; sulfuric acid 1.) 0.05 M phosphate buffer (pH 7), toluene, 4.5 h, 2.) dioxane, 22-24 psi, RT, 21 h; Yield given. Multistep reaction. Yields of byproduct given;