(2R,3R)-3-(Boc-氨基)-2-羟基-4-苯基丁酸合成路线 （共 21 条）
反应条件
sodium hydroxide in water; toluene T=0°C; 21 h;
参考文献
EP1403257 A1, ;
Page 14 ;
反应条件
potassium hydroxide; 3'-phenoxy-4'-fluoro-α'-cyanobenzyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropane-carboxylate in hexane; water; ethyl acetate; acetonitrile
参考文献
AJINOMOTO CO. INC
Patent: US2002/151722 A1, 2002 ;
反应条件
triethylamine in N,N-dimethyl-formamide
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 8 p. 2425 - 2429
反应条件
sodium hydroxide; sodium carbonate; citric acid in tetrahydrofuran; ethyl acetate
反应条件
1: 67 percent / LDA / pentane; ethylbenzene; tetrahydrofuran / 1 h / -78 °C 2: NaOH / toluene; H2O / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 36 p. 6337 - 6340
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile T=35°C; pH=6.7;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 11 p. 1201 - 1208
反应条件
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / Heating 1.2: tetrahydrofuran / 0.5 h / 0 °C 2.1: aq. H2O2; aq. NaHCO3 / methanol; tetrahydrofuran / 2.5 h / 70 °C 3.1: 1.14 g / H2 / 5 percent Pd/C / ethanol / 6.5 h / 50 °C 4.1: methanol / 2 h / 20 °C 5.1: TEMPO; NaClO2; NaClO / aq. phosphate buffer; acetonitrile / 35 °C / pH 6.7 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 11 p. 1201 - 1208
反应条件
1: 1.14 g / H2 / 5 percent Pd/C / ethanol / 6.5 h / 50 °C 2: methanol / 2 h / 20 °C 3: TEMPO; NaClO2; NaClO / aq. phosphate buffer; acetonitrile / 35 °C / pH 6.7 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 11 p. 1201 - 1208
反应条件
1: aq. H2O2; aq. NaHCO3 / methanol; tetrahydrofuran / 2.5 h / 70 °C 2: 1.14 g / H2 / 5 percent Pd/C / ethanol / 6.5 h / 50 °C 3: methanol / 2 h / 20 °C 4: TEMPO; NaClO2; NaClO / aq. phosphate buffer; acetonitrile / 35 °C / pH 6.7 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 11 p. 1201 - 1208
反应条件
1.1: H2O; ethyl acetate 1.2: 6.45 g / conc. HCl / dioxane / 8 h / Heating 2.1: 32.5 percent / TEA / tetrahydrofuran; H2O View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 35, # 10 p. 887 - 894
