1,3-二苯基-1H-吡唑-4-羧酸合成路线 （共 12 条）
反应条件
pyridine; potassium permanganate in water T=20 - 22°C;
参考文献
Bratenko; Chornous; Vovk
Russian Journal of Organic Chemistry, 2001 , vol. 37, # 4 p. 552 - 555
反应条件
1.1: 25 °C 1.2: dimethylformamide / 16 h / 20 °C 2.1: 1.12 g / aq. Na2CO3 3.1: aq. NaHCO3; NaBr; trichloroisocyanuric acid / TEMPO / acetone / 20 °C View Scheme
参考文献
Synlett, , # 13 p. 2299 - 2302
反应条件
1: sodium acetate / ethanol / 3 h / 50 - 60 °C 2: trichlorophosphate / 6 h / 50 - 60 °C / Cooling 3: sodium chlorite; aminosulfonic acid / acetone / 5 h / 40 - 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 11 p. 3589 - 3593
反应条件
triethylamine; sodium iodide in acetonitrile T=20°C;
参考文献
Clovis, James S.; Fliege, Werner; Huisgen, Rolf
Chemische Berichte, 1983 , vol. 116, # 9 p. 3062 - 3070
反应条件
1.1: 25 °C 1.2: dimethylformamide / 16 h / 20 °C 2.1: 1.12 g / aq. Na2CO3 3.1: aq. NaHCO3; NaBr; trichloroisocyanuric acid / TEMPO / acetone / 20 °C View Scheme
参考文献
Synlett, , # 13 p. 2299 - 2302
反应条件
1: sodium acetate / ethanol / 3 h / 50 - 60 °C 2: trichlorophosphate / 6 h / 50 - 60 °C / Cooling 3: sodium chlorite; aminosulfonic acid / acetone / 5 h / 40 - 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 11 p. 3589 - 3593
反应条件
potassium hydroxide; triethylamine; sodium iodide 1) acetonitrile, 20 deg C, 24 h, 2) EtOH, reflux; Multistep reaction. Title compound not separated from byproducts;
参考文献
Chemische Berichte, , vol. 116, # 9 p. 3062 - 3070
反应条件
1: SOCl2 / 1 h / Heating 2: 69 percent / NH3 / 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971
反应条件
1: SOCl2 / 1 h / Heating 2: 70.8 percent / benzene; 1,2-dichloro-ethane / Ambient temperature View Scheme
参考文献
Zagorevskii, V. A.; Vlasova, N. V.; Zykov, D. A.; Kirsanova, Z. D.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 8 p. 684 - 689
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 8 p. 966 - 971
反应条件
tetrabutyl-ammonium chloride; caesium carbonate; triphenylphosphine; palladium dichloride in N,N-dimethyl-formamide
T=160°C; 0.333333 h; Microwave irradiation;
参考文献
Pandey, Garima; Bhowmik, Subhendu; Batra, Sanjay
Organic Letters, 2013 , vol. 15, # 19 p. 5044 - 5047
