2-[(三甲基硅基)乙炔基]苯甲醛合成路线 （共 35 条）
反应条件
1: diethyl ether 2: 90 percent / potassium carbonate / methanol / 0.33 h / 20 °C 3: 46.3 percent / DEAD; PPh3; o-nitrobenzenesulfonylhydrazine / tetrahydrofuran / 8 h / 20 °C View Scheme
参考文献
Hughes, Thomas S.; Carpenter, Barry K.
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 11 p. 2291 - 2298
反应条件
1.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C 1.2: tetrahydrofuran; toluene / 3 h / -78 - 0 °C 2.1: K2CO3; methanol / 2 h / 20 °C 3.1: 691 mg / aq. HCl / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Huple, Deepak B.; Ghorpade, Satish; Liu, Rai-Shung
Chemistry - A European Journal, 2013 , vol. 19, # 39 p. 12965 - 12969
反应条件
ammonia in ethanol T=80°C; Cyclization; 2 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 5 p. 669 - 672
反应条件
1.1: n-BuLI / tetrahydrofuran / 0.5 h / 0 °C 1.2: tetrahydrofuran / 4 h / 20 °C 2.1: Bu4NF / tetrahydrofuran / 8 h / 26 °C 3.1: m-chloroperbenzoic acid / CH2Cl2 / 3 h / 28 °C 4.1: 95 percent / [tris(1-pyrazolyl)borate]RuPPh3(CH3CN)2PF6 / toluene / 3 h / 100 °C View Scheme
参考文献
Madhushaw, Reniguntala J.; Lin, Ming-Yuan; Abu Sohel, Shariar Md.; Liu, Rai-Shung
Journal of the American Chemical Society, 2004 , vol. 126, # 22 p. 6895 - 6899
反应条件
oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N'-di(2,4,6-trimethylphenyl)-4,5-dihydroimidazolinium chloride in acetonitrile T=80°C; 7 h; regioselective reaction;
参考文献
Park, Jong Hyub; Bhilare, Sachin V.; Youn, So Won
Organic Letters, 2011 , vol. 13, # 9 p. 2228 - 2231
反应条件
1: methanol; potassium carbonate / 1 h / 20 °C 2: oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N'-di(2,4,6-trimethylphenyl)-4,5-dihydroimidazolinium chloride / acetonitrile / 12 h / 80 °C View Scheme
参考文献
Park, Jong Hyub; Bhilare, Sachin V.; Youn, So Won
Organic Letters, 2011 , vol. 13, # 9 p. 2228 - 2231
反应条件
1: ammonium acetate / 1 h / 110 °C 2: sodium azide / dimethyl sulfoxide / 0.5 h / 100 °C View Scheme
参考文献
Arigela, Rajesh K.; Samala, Srinivas; Mahar, Rohit; Shukla, Sanjeev K.; Kundu, Bijoy
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10476 - 10484
反应条件
1: 80 percent / n-BuLi / tetrahydrofuran; hexane / 5 h / 0 - 23 °C 2: 91 percent / BaMnO4 / CH2Cl2 / 72 h / 23 °C 3: 32 percent / 14 h / 180 °C / solid state, celite View Scheme
参考文献
Gonzalez-Cantalapiedra, Esther; De Frutos, Oscar; Atienza, Carmen; Mateo, Cristina; Echavarren, Antonio M.
European Journal of Organic Chemistry, 2006 , # 6 p. 1430 - 1443
反应条件
1: 83 percent / NH2OH*HCl, AcONa / ethanol; H2O / 0.5 h / 60 °C 2: 44 percent / K2CO3 / ethanol; H2O / 60 °C View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Miura, Norio; Hayashi, Kazuhiko; Yamanaka, Hiroshi
Heterocycles, 1986 , vol. 24, # 8 p. 2311 - 2314
反应条件
1: tetrahydrofuran 2: PDC / CH2Cl2 View Scheme
参考文献
Shindo; Sato; Shishido
Journal of Organic Chemistry, 2001 , vol. 66, # 23 p. 7818 - 7824
