2-氨基-3,4-二甲基-3H-咪唑并喹啉合成路线 （共 12 条）
反应条件
1: Fe, conc. aq. HCl / 0.33 h 2: H2O / 4 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
1: 75 percent / HNO3, conc. H2SO4 / 0.5 h / 0 °C 2: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 3: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 4: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 5: 68 percent / HNO3, H2SO4 / 1 h / 0 °C 6: 80 percent / SnCl2, HCl / 1 h / 100 °C 7: ethanol / 2 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
反应条件
1: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 2: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 4: 68 percent / HNO3, H2SO4 / 1 h / 0 °C 5: 80 percent / SnCl2, HCl / 1 h / 100 °C 6: ethanol / 2 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
反应条件
1: 85 percent / H2O; aq. ethanol / 4 h / Heating 2: 69 percent / hydrogen / Raney nickel / ethanol / 1.5 h / Ambient temperature 3: 2.) conc. ammonia / 1.) methanol, 4 h View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 37, # 2 p. 157 - 159
反应条件
1: 110 mg / 0.17 h / Ambient temperature 2: 500 mg / KNO3, conc. H2SO4 / 0.5 h / Ambient temperature 3: 360 mg / conc. H2SO4 / 0.5 h / 70 °C 4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h 5: Fe, conc. aq. HCl / 0.33 h 6: H2O / 4 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Chemistry Letters, , p. 1391 - 1394
反应条件
1: 500 mg / KNO3, conc. H2SO4 / 0.5 h / Ambient temperature 2: 360 mg / conc. H2SO4 / 0.5 h / 70 °C 3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h 4: Fe, conc. aq. HCl / 0.33 h 5: H2O / 4 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h 2: Fe, conc. aq. HCl / 0.33 h 3: H2O / 4 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
1: 360 mg / conc. H2SO4 / 0.5 h / 70 °C 2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h 3: Fe, conc. aq. HCl / 0.33 h 4: H2O / 4 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
1: 68 percent / HNO3, H2SO4 / 1 h / 0 °C 2: 80 percent / SnCl2, HCl / 1 h / 100 °C 3: ethanol / 2 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
