L-3-N-Boc-2,3-二氨基丙酸甲酯合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated charcoal in methanol 24 h;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: 95 percent / aq. NaHCO3 / CH2Cl2 / 4 h / Ambient temperature 2: 99 percent / H2 / 10 percent Pd/C / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 13 p. 2409 - 2421
反应条件
triethylamine in dichloromethane T=0°C; 1.5 h;
参考文献
Synthetic Communications, , vol. 23, # 5 p. 703 - 709
反应条件
1: 79.5 percent / diethyl ether 2: 100 percent / H2 / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: 88.4 percent / 1 N aq. NaoH / dioxane / 48 h / 45 °C 2: Na, NH3(liq.) / 0.17 h / -50 °C 3: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 4: 79.5 percent / diethyl ether 5: 100 percent / H2 / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: Na, NH3(liq.) / 0.17 h / -50 °C 2: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 3: 79.5 percent / diethyl ether 4: 100 percent / H2 / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 2: 79.5 percent / diethyl ether 3: 100 percent / H2 / 10percent Pd/C / methanol / 24 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: NaOMe / methanol / 1 h / -10 °C 2: H2 View Scheme
参考文献
Synthesis, , # 7 p. 542 - 544
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere 1.2: 18 h / 20 °C / Inert atmosphere 2.1: diethylamine / methanol / 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 18 p. 3153 - 3157
反应条件
pyridine in acetonitrile 5 h; Ambient temperature;
参考文献
Egbertson; Homnick; Hartman
Synthetic Communications, 1993 , vol. 23, # 5 p. 703 - 709
