1,4-二羟基-2-萘甲酸甲酯合成路线 （共 14 条）
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Essilor International (Compagnie Generale D'Optique)
Patent: EP2098520 A1, 2009 ;
Location in patent: Page/Page column 15 ;
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 10 h;
参考文献
Yong, Rok Lee; Yun, Mi Kim
Helvetica Chimica Acta, 2007 , vol. 90, # 12 p. 2401 - 2413
反应条件
in diethyl ether T=0°C;
参考文献
Brimble, Margaret A.; Spicer, Julie A.
Australian Journal of Chemistry, 1991 , vol. 44, # 2 p. 197 - 205
反应条件
in tetrahydrofuran; methanol; diethyl ether T=-30°C; 0.75 h; Inert atmosphere;
参考文献
Yamamoto, Yoshihiko; Itonaga, Kouhei
Organic Letters, 2009 , vol. 11, # 3 p. 717 - 720
反应条件
ammonium acetate; acetic acid 4 h; Reflux;
参考文献
Tetrahedron, , vol. 67, # 45 p. 8747 - 8756
反应条件
N-chloro-succinimide; water in acetone 3 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 10 p. 1785 - 1789
反应条件
1: 52 percent / Na / ethanol / 2.5 h 2: 87 percent / sodium hydroxide, sodium thiosulfate / H2O / 18 h / Ambient temperature 3: 79 percent / ethyldiisopropylamine / dimethylformamide / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 17 p. 3474 - 3478
反应条件
1: 87 percent / sodium hydroxide, sodium thiosulfate / H2O / 18 h / Ambient temperature 2: 79 percent / ethyldiisopropylamine / dimethylformamide / 1 h / 85 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 17 p. 3474 - 3478
反应条件
1: 94 percent / p-toluenesulfonic acid / 8 h / Heating 2: 82 percent / H2SO4 / 15 h / Heating 3: 1.) iPr2NLi, HMPA / 1.) THF, -78 deg C, 2.) THF, RT, 8 h 4: 5 percent / NCS, H2O / acetone / 3 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 10 p. 1785 - 1789
反应条件
1: 82 percent / H2SO4 / 15 h / Heating 2: 1.) iPr2NLi, HMPA / 1.) THF, -78 deg C, 2.) THF, RT, 8 h 3: 5 percent / NCS, H2O / acetone / 3 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 10 p. 1785 - 1789
