2-[(二甲基氨基)甲基]环己酮合成路线 （共 38 条）
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere; optical yield given as percent de;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 1; 8-9 ;
反应条件
in tetrahydrofuran stereoselective reaction;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
sodium hydroxide in water T=96 - 98°C; 5 h; Yield given;
参考文献
Akimova, T. I.; Kosenko, S. V.; Tilichenko, M. N.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 12 p. 2271 - 2277
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 12 p. 2553 - 2560
反应条件
T=110 - 130°C; 3 h; Further byproducts given;
参考文献
Akimova, T. I.; Kosenko, S. V.; Tilichenko, M. N.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 12 p. 2271 - 2277
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 12 p. 2553 - 2560
参考文献
Akimova, T. I.; Kosenko, S. V.; Tilichenko, M. N.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 12 p. 2271 - 2277
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 12 p. 2553 - 2560
反应条件
in tetrahydrofuran T=20°C; Grignard reaction; 0.55 h; Inert atmosphere; optical yield given as percent de;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
1: 3-methoxybromobenzene With magnesium in tetrahydrofuran T=55 - 120°C; 2: With lithium chloride in tetrahydrofuran; ethylene glycol dimethyl ether T=25°C; 0.5 h; 3: (RS)-2-dimethylaminomethyl-cyclohexanone With water; ammonium chloride Product distribution / selectivity; more than 3 stages;
参考文献
GRUeNENTHAL GMBH
Patent: WO2004/20390 A1, 2004 ;
Location in patent: Page/Page column 1; 8-9 ;
反应条件
in tetrahydrofuran stereoselective reaction;
参考文献
Zhang, Xini; Stefanick, Stephen; Villani, Frank J.
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 455 - 460
反应条件
dichloro bis(acetonitrile) palladium(II); triethylamine in acetonitrile 0.5 h; Heating;
参考文献
Murahashi, Shun-Ichi; Mitsue, Yo; Tsumiyama, Tatsuo
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 9 p. 3285 - 3290
