2-氧代-4,6-二甲基-1,2-二氢吡啶-3-甲腈合成路线 （共 62 条）
反应条件
acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane T=70°C; 3 h;
参考文献
Chen, Liuqing; Liu, Xuguang; Xu, Bingshe; Sun, Chunyan; Tao, Peng
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2011 , vol. 79, # 5 p. 1926 - 1930
反应条件
morpholine in methanol T=65°C;
参考文献
BIAL - PORTELA and Cª., S.A.; RUSSO, Domenico; KISS, Laszlo Erno; WAHNON, Jorge Bruno Reis; LEARMONTH, David Alexander; ESZENYI, Tibor; ZIMMERMANN, Axel; SCHLUMMER, Bjoern; KREIS, Michael; REITER, Klaus
Patent: WO2013/89573 A1, 2013 ;
Location in patent: Page/Page column 14 ;
反应条件
in tetrahydrofuran T=65°C; Cyclization; addition; elimination; Dimroth rearrangement; 1 h;
参考文献
Alberola, Angel; Calvo, Luis A.; Ortega, Alfonso Gonzalez; Ruiz, M. Carmen Sanudo; Yustos, Pedro; Granda, Santiago Garcia; Garcia-Rodriguez, Esther
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9493 - 9498
反应条件
in tetrahydrofuran T=65°C; Cyclization; addition; elimination; Dimroth rearrangement; 2 h;
参考文献
Alberola, Angel; Andres, Celia; Ortega, Alfonso Gonzalez; Pedrosa, Rafael; Vicente, Martina
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 709 - 713
反应条件
in tetrahydrofuran T=65°C; Cyclization; addition; elimination; Dimroth rearrangement; 2 h;
参考文献
Alberola, Angel; Calvo, Luis A.; Ortega, Alfonso Gonzalez; Ruiz, M. Carmen Sanudo; Yustos, Pedro; Granda, Santiago Garcia; Garcia-Rodriguez, Esther
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9493 - 9498
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride 4 h;
参考文献
Hawaldar, V. S.; Sunthankar, S. V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 151 - 152
反应条件
1: H2 / Raney nickel / ethanol / 24 h / 20 °C / 20685.9 Torr 2: ethanol / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 51 p. 8981 - 8984
反应条件
sodium ethanolate in ethanol 7 h; Heating;
参考文献
Katoh, Akira; Omote, Yoshimori; Kashima, Choji
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 8 p. 2942 - 2946
反应条件
sodium ethanolate in ethanol 24 h; Heating;
参考文献
Katoh, Akira; Omote, Yoshimori; Kashima, Choji
Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 8 p. 2942 - 2946
反应条件
in tetrahydrofuran 8 h; Ambient temperature;
参考文献
Alberola, Angel; Andres, Celia; Ortega, Alfonso Gonzalez; Pedrosa, Rafael; Vicente, Martina
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 709 - 713
