2,4,6-三级甲基苯乙炔合成路线 （共 19 条）
反应条件
n-butyl lithium in not given treatment of mesithylethyne with n-BuLi, react. with fluoro(dimesityl)borane;
参考文献
Eisch, John J.; Shafii, Babak; Rheingold, Arnold L.
Journal of the American Chemical Society, 1987 , vol. 109, # 8 p. 2526 - 2528
反应条件
water; perchloric acid T=25°C; Rate constant;
参考文献
Banait, N.; Hojatti, M.; Findlay, P.; Kresge, A. J.
Canadian Journal of Chemistry, 1987 , vol. 65, p. 441 - 444
反应条件
1: 2,4,6-trimethylphenyl iodide; trimethylsilylacetylene With potassium carbonate in methanol; acetonitrile
T=45°C; Sonogashira Cross-Coupling;
2: 2,4,6-trimethylphenyl iodide in methanol; acetonitrile
T=45°C; Sonogashira Cross-Coupling;
参考文献
Mandali, Pavan Kumar; Chand, Dillip Kumar
Catalysis Communications, 2014 , vol. 47, p. 40 - 44
反应条件
potassium carbonate in methanol; acetonitrile
T=45°C; Sonogashira Cross-Coupling;
参考文献
Mandali, Pavan Kumar; Chand, Dillip Kumar
Catalysis Communications, 2014 , vol. 47, p. 40 - 44
反应条件
potassium tert-butylate in dimethyl sulfoxide
参考文献
Yates, Keith; Mandrapilias, George
Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3902 - 3906
反应条件
n-butyllithium in diethyl ether; hexane
T=-78 - 20°C; Inert atmosphere;
参考文献
Dixon, Luke I.; Carroll, Michael A.; Gregson, Thomas J.; Ellames, George J.; Harrington, Ross W.; Clegg, William
European Journal of Organic Chemistry, 2013 , # 12 p. 2334 - 2345
反应条件
(i) PCl5, (ii) NaNH2; Multistep reaction;
参考文献
Johnson,T.R.; Walton,D.R.M.
Tetrahedron, 1972 , vol. 28, p. 5221 - 5236
反应条件
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine / tetrahydrofuran / 17 h / 50 °C / Inert atmosphere
2.1: sodium hydroxide / methanol / 4 h / 20 °C / Inert atmosphere
2.2: Inert atmosphere
View Scheme
参考文献
Kloss, Florian; Koehn, Uwe; Jahn, Burkhard O.; Hager, Martin D.; Goerls, Helmar; Schubert, Ulrich S.
Chemistry - An Asian Journal, 2011 , vol. 6, # 10 p. 2816 - 2824
反应条件
magnesium
1.) THF, -78 deg C, 30 min, 2.) reflux, 50 h; Yield given. Multistep reaction;
参考文献
Eisch, John J.; Shafii, Babak; Odom, Jerome D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1847 - 1853
反应条件
1.1: hydrogenchloride / water / Cooling with ice
1.2: 0.83 h / -5 °C
1.3: 76 h / 20 °C
2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine / tetrahydrofuran / 17 h / 50 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 4 h / 20 °C / Inert atmosphere
3.2: Inert atmosphere
View Scheme
参考文献
Kloss, Florian; Koehn, Uwe; Jahn, Burkhard O.; Hager, Martin D.; Goerls, Helmar; Schubert, Ulrich S.
Chemistry - An Asian Journal, 2011 , vol. 6, # 10 p. 2816 - 2824
