反应条件
1: 1.) t-BuLi, 3.) n-BuLi, 4.) I2 2: 92 percent / Et3SIH, TFA 3: 1.) n-BuLi 4: 76 percent / 2 N aq. NaOH / ethanol 5: 1.) TMSCl, NaI, Dabco, 2.) 6 N aq. HCl / 1.) CH3CN, reflux, 5 h, 2.) 100 deg C, 4 h 6: 95 percent / H2, NaOAc / Pd/C / methanol 7: 87 percent / t-BuOK / 1,2-dimethoxy-ethane / 48 h / Heating 8: 59 percent / Pd(OAc)2, Bu4N(1+)*Br(1-), KOAc / dimethylformamide / 3 h / 90 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 27 p. 10971 - 10972
