1-苄基-4-(2-羟乙基)哌啶合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 20 h; Heating;
参考文献
Contreras; Parrot; Sippl; Rival; Wermuth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2707 - 2718
反应条件
1: 90 percent / NaH / tetrahydrofuran 2: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Synthetic Communications, , vol. 33, # 13 p. 2329 - 2338
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 18 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4344 - 4361
反应条件
1: potassium carbonate / dimethylformamide / 70 °C 2: aq.HCl / benzene / 24 h / Heating 3: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h 4: 91 percent / LAH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 3 p. 749 - 756
反应条件
1: potassium carbonate / dimethylformamide / 70 °C 2: aq.HCl / benzene / 24 h / Heating 3: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h 4: 91 percent / LAH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 3 p. 749 - 756
反应条件
1: aq.HCl / benzene / 24 h / Heating 2: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h 3: 91 percent / LAH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 3 p. 749 - 756
反应条件
1: K2CO3 / ethanol / 72 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4344 - 4361
反应条件
1: K2CO3 / ethanol / 72 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 23 p. 4344 - 4361
反应条件
1.1: NaBH4 / CH2Cl2 / 5 h / Heating 2.1: aq. HCl / methanol 3.1: 97 percent / aq. NaOH / 80 h / Heating 4.1: aq. HCl / 48 h / Heating 4.2: 75 percent / aq. HCl / 20 °C 5.1: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 13 p. 2329 - 2338
反应条件
1.1: NaBH4 / CH2Cl2; acetic acid / 0 - 20 °C 2.1: NaBH4 / CH2Cl2 / 5 h / Heating 3.1: aq. HCl / methanol 4.1: 97 percent / aq. NaOH / 80 h / Heating 5.1: aq. HCl / 48 h / Heating 5.2: 75 percent / aq. HCl / 20 °C 6.1: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 13 p. 2329 - 2338
