1: 4-bromo-phenol With di-isopropyl azodicarboxylate; triphenylphosphine; Wang resin in tetrahydrofuran
T=20°C;
2: dihydroxy(3-fluorophenyl)borane With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water
T=80°C; Suzuki reaction;
3: With trifluoroacetic acid in dichloromethane
0.166667 h;
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474