(R)-(+)-2-溴-3-甲基丁酸合成路线 （共 20 条）
反应条件
sulfuric acid; potassium bromide; sodium nitrite T=0 - 20°C;
参考文献
Yao, Zhiyi; Du, Xiaojie; Liu, Hong; Jiang, Hualiang; Chen, Kaixian
Journal of Chemical Research, 2006 , # 1 p. 3 - 5
反应条件
1: With hydrogen bromide in hexane; water T=0°C; 2: With sodium nitrite in hexane; water T=-5°C; 10 h; 3: in hexane; water T=-5°C;
参考文献
EP1481960 A1, ;
Page 8 ;
反应条件
1: With hydrogen bromide in water; toluene T=0°C; 2: With sodium nitrite in water; toluene T=-5°C; 10 h; 3: in water; toluene T=-5°C;
参考文献
EP1481960 A1, ;
Page 8 ;
反应条件
2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methylmorpholine N-oxide in tetrahydrofuran T=-10°C; 2 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 2, # 4 p. 238 - 244
反应条件
1: 84 percent / triethylamine / CH2Cl2 / 4 h / 0 °C 2: 2 N aq. HCl / acetic acid / 4 h / 120 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 8, # 11 p. 1877 - 1894
反应条件
1: 95 percent / DMAP, DCC / CH2Cl2 / 0 - 20 °C 2: n-BuLi, iPr2NH / tetrahydrofuran; hexane / 6 h / -70 - 20 °C 3: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C 4: 30percent aq. H2O2, LiOH / tetrahydrofuran / 0.5 h View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 8 p. 1919 - 1932
反应条件
1: n-BuLi, iPr2NH / tetrahydrofuran; hexane / 6 h / -70 - 20 °C 2: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C 3: 30percent aq. H2O2, LiOH / tetrahydrofuran / 0.5 h View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 8 p. 1919 - 1932
反应条件
1: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C 2: 30percent aq. H2O2, LiOH / tetrahydrofuran / 0.5 h View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 8 p. 1919 - 1932
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran 0.5 h; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 8 p. 1919 - 1932
反应条件
durch fraktionierte Krystallisation des Cinchonidinsalzes aus Aceton;
参考文献
Journal of Biological Chemistry, , vol. 75, p. 344
