(4R)-1-苯甲氧基-4-[(2,4,5-三氟苯基)甲基]-2-氮杂环丁酮合成路线 （共 2 条）
反应条件
1.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3 1.2: 3 h / 0 - 5 °C 2.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C 3.1: sodium hydroxide / water / 1 h / 0 - 5 °C 4.1: phosphoric acid; water / water; isopropyl alcohol / 0.25 h View Scheme
参考文献
Sathe, Dhananjay Govind; Damle, Subhash Vishwanath; Arote, Nitin Dnyaneshwar; Ambre, Rakesh Ramchandra; Want, Kamlesh Digambar; Naik, Tushar Anil
Patent: US2013/158265 A1, 2013 ;
反应条件
1.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2.33 h / 20 - 25 °C / pH 3
1.2: 3 h / 0 - 5 °C
2.1: phosphoric acid / isopropyl alcohol / 16 h / 30 °C
3.1: sodium hydroxide / water / 1 h / 0 - 5 °C
View Scheme
参考文献
Sathe, Dhananjay Govind; Damle, Subhash Vishwanath; Arote, Nitin Dnyaneshwar; Ambre, Rakesh Ramchandra; Want, Kamlesh Digambar; Naik, Tushar Anil
Patent: US2013/158265 A1, 2013 ;
