in ethanol 0.5 h; Ambient temperature;

1: aq. NaOH 2: 70 percent / t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature 3: 1.) n-BuLi, diisopropylamine / 1.) hexane, THF, HMPA, -60 deg C, 2.) hexane, THF, HMPA, -60 deg C, 1 h View Scheme

1: 97 percent / ethanol / 1.5 h / Heating 2: aq. NaOH / 0.33 h / 70 °C 3: aq. NaOH 4: 70 percent / t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature 5: 1.) n-BuLi, diisopropylamine / 1.) hexane, THF, HMPA, -60 deg C, 2.) hexane, THF, HMPA, -60 deg C, 1 h View Scheme

1: aq. NaOH / 0.33 h / 70 °C 2: aq. NaOH 3: 70 percent / t-BuOK / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / Ambient temperature 4: 1.) n-BuLi, diisopropylamine / 1.) hexane, THF, HMPA, -60 deg C, 2.) hexane, THF, HMPA, -60 deg C, 1 h View Scheme

n-butyllithium; diisopropylamine 1.) hexane, THF, HMPA, -60 deg C, 2.) hexane, THF, HMPA, -60 deg C, 1 h; Yield given. Multistep reaction;