2-(氯甲基)-5-甲基吡啶合成路线 （共 5 条）
反应条件
1: aqueous ethanol 2: aqueous hydrochloric acid View Scheme
参考文献
Arata; Achiwa
Yakugaku Zasshi, 1959 , vol. 79, p. 108
Chem.Abstr., 1959 , p. 10211
反应条件
1: With thionyl chloride in methanol
0.0833333 h; Heating / reflux;
2: With water; sodium hydrogencarbonate in diethyl ether
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2007/105904 A1, 2007 ;
Location in patent: Page/Page column 88 ;
反应条件
1: With p-toluenesulfonyl chloride in dichloromethane
T=40°C; 2 h;
2: With triethylamine in dichloromethane
T=40°C; 3 h;
参考文献
Tachdjian, Catherine; Lebl-Rinnova, Marketa; Wallace, David
Patent: US2006/263411 A1, 2006 ;
Location in patent: Page/Page column 35 ;
反应条件
1: 2N aq. NaOH / methanol / 2 h / 25 °C
2: SOCl2 / CH2Cl2 / 2 h / 25 °C
View Scheme
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
反应条件
1: aqueous ethanol
2: ethanolic HCl
View Scheme
参考文献
Arata; Achiwa
Yakugaku Zasshi, 1959 , vol. 79, p. 108
Chem.Abstr., 1959 , p. 10211
