1-(N-((苯基甲氧基)羰基)-L-苯丙氨酰)-L-脯氨酸合成路线 (共 17 条)
反应条件
carboxypeptidase-Y in water T=37°C; pH=6.5; Kinetics;
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
参考文献
Nishikata; Yokosawa; Ishii
Chemical and pharmaceutical bulletin, 1986 , vol. 34, # 7 p. 2931 - 2936
反应条件
triethylamine in water; acetonitrile
T=50°C; 0.166667 h; Microwave irradiation;
参考文献
Monbaliu, Jean-Christophe M.; Hansen, Finn K.; Beagle, Lucas K.; Panzner, Matthew J.; Steel, Peter J.; Todadze, Ekaterina; Stevens, Christian V.; Katritzky, Alan R.
Chemistry - A European Journal, 2012 , vol. 18, # 9 p. 2632 - 2638
反应条件
sodium hydroxide in N,N-dimethyl-formamide
T=20°C;
参考文献
Sobirov, M.M.; Khalikov, Sh.Kh.; Saidov, S.S.; Kodirov, M.Z.; Zaitsev, S.V.; et al.
Russian Journal of Bioorganic Chemistry, 1994 , vol. 20, # 7 p. 397 - 405
Bioorganicheskaya Khimiya, 1994 , vol. 20, # 7 p. 740 - 750
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -15 °C
2: CH2Cl2 / 0 - 20 °C
3: aq. LiOH / tetrahydrofuran / 0 - 22 °C
View Scheme
参考文献
Wipf, Peter; Fritch, Paul C.
Journal of the American Chemical Society, 1996 , vol. 118, # 49 p. 12358 - 12367
反应条件
1: CH2Cl2 / 0 - 20 °C
2: aq. LiOH / tetrahydrofuran / 0 - 22 °C
View Scheme
参考文献
Wipf, Peter; Fritch, Paul C.
Journal of the American Chemical Society, 1996 , vol. 118, # 49 p. 12358 - 12367
反应条件
sodium carbonate in 1,4-dioxane
0.00833333 h; microwave irradiation;
参考文献
Suresh Babu, Vommina V.; Ramana Rao
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2328 - 2332
反应条件
triethylamine in tetrahydrofuran; water
7 h; Ambient temperature;
参考文献
Kouge; Koizumi; Okai; Kato
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418
反应条件
triethylamine in water; acetonitrile
T=20°C; 1 h; Title compound not separated from byproducts.;
参考文献
Katritzky, Alan R.; Todadze, Ekaterina; Angrish, Parul; Draghici, Bogdan
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5794 - 5801
反应条件
triethylamine in water
12 h; Ambient temperaturepH=10.0;
参考文献
Kouge; Koizumi; Okai; Kato
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418