(4-苄基-2-吗啉)-乙酸甲酯合成路线 （共 4 条）
反应条件
1: With sulfuric acid T=0°C; 12 h; Reflux; 2: With sodium hydroxide in water pH=14;
参考文献
HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol
Patent: WO2012/128582 A2, 2012 ;
Location in patent: Page/Page column 45 ;
WO 2012/128582 A2
反应条件
1.1: 1 h / 50 °C 1.2: 2 h / Reflux 1.3: 20 °C / pH 14 2.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 5 h / Reflux 3.1: sulfuric acid / 12 h / 0 °C / Reflux 3.2: pH 14 View Scheme
参考文献
WO2012/128582 A2, ;
WO 2012/128582 A2
反应条件
1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 5 h / Reflux 2.1: sulfuric acid / 12 h / 0 °C / Reflux 2.2: pH 14 View Scheme
参考文献
WO2012/128582 A2, ;
WO 2012/128582 A2
反应条件
1: With potassium hydroxide in methanol; water T=20°C; pH=7; 12 h; 2: With hydrogenchloride in water pH=7;
参考文献
HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol
Patent: WO2012/128582 A2, 2012 ;
Location in patent: Page/Page column 45-46 ;
WO 2012/128582 A2
