3,4-二溴-5-羟基呋喃-2(5h)-酮合成路线 （共 21 条）
反应条件
1: With sodium nitrite in ethanol; water T=50 - 55°C; 1 h; 2: With water in ethanol 0.25 h; Reflux;
参考文献
WO2012/135631 A1, ;
Page/Page column 16 ;
WO 2012/135631 A1
反应条件
diboron trioxide in methanol T=180 - 185°C; 15 h;
参考文献
Kress, Thomas J.; Szymanski, Edward
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1721 - 1722
反应条件
scandium tris(trifluoromethanesulfonate) in diethyl ether T=-20 - 18°C; Mukaiyama aldol reaction; 21 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: US2006/4211 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
sodium methylate in diethyl ether
参考文献
Canevet, J. C.; Sharrard, F.
Tetrahedron Letters, 1982 , vol. 23, # 2 p. 181 - 184
反应条件
1: 3',4'-difluoroaniline With hydrogen bromide; sodium nitrite in water T=-5 - 0°C; 0.5 h; 2: With hydrogen bromide; tin(ll) chloride in water T=0°C; 2 h; 3: mucobromic acid in water T=80 - 90°C;
参考文献
Zhang, Ji; Morton, Howard E.; Ji, Jianguo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735
参考文献
Zhang, Ji; Morton, Howard E.; Ji, Jianguo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735
反应条件
in water Inert atmosphereReflux;
参考文献
Kerdesky, Francis A. J.; Leanna, M. Robert; Zhang, Ji; Li, Wenke; Lallaman, John E.; Ji, Jianguo; Morton, Howard E.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 512 - 517
反应条件
sodium ethanolate in ethanol T=20 - 56°C;
参考文献
ASTRAZENECA AB
Patent: WO2006/4532 A1, 2006 ;
Location in patent: Page/Page column 21 ;
WO 2006/004532 A1
反应条件
1: 3-trifluoromethyl-aniline With hydrogen bromide; sodium nitrite in water T=-5 - 0°C; 0.5 h; 2: With hydrogen bromide; tin(ll) chloride in water T=0°C; 2 h; 3: mucobromic acid in water T=80 - 90°C;
参考文献
Zhang, Ji; Morton, Howard E.; Ji, Jianguo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735
反应条件
1: aniline With hydrogen bromide; sodium nitrite in water T=-5 - 0°C; 0.5 h; 2: With hydrogen bromide; tin(ll) chloride in water T=0°C; 2 h; 3: mucobromic acid in water T=80 - 90°C;
参考文献
Zhang, Ji; Morton, Howard E.; Ji, Jianguo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8733 - 8735
