N-乙酰基-L-半胱氨酸甲酯合成路线 （共 23 条）
反应条件
triethylamine in toluene Ambient temperature;
参考文献
Van Bladeren; Buys; Breimer; Van Der Gen
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 6 p. 495 - 497
反应条件
2-chloro-1-methyl-pyridinium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere;
参考文献
Lin, Yuya A.; Boutureira, Omar; Lercher, Lukas; Bhushan, Bhaskar; Paton, Robert S.; Davis, Benjamin G.
Journal of the American Chemical Society, 2013 , vol. 135, # 33 p. 12156 - 12159
反应条件
in methanol-d4 T=45°C; 42 h; alkylation lacking triethylamine and with excess of methyloxirane;
参考文献
Ellis, Martin K.; Golding, Bernard T.; Watson, William P.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 11 p. 1737 - 1744
反应条件
in dimethylsulfoxide-d6 T=25°C;
参考文献
Pharmacological Research, , vol. 63, # 1 p. 30 - 36
反应条件
sodium hydrogencarbonate in methanol; water T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 14 p. 4162 - 4172
反应条件
sodium hydrogencarbonate in methanol; water T=20°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 16, # 9 p. 5039 - 5049
反应条件
sodium hydrogencarbonate in methanol; water T=20°C; Inert atmosphere;
参考文献
Kuramochi, Kouji; Sunoki, Takashi; Tsubaki, Kazunori; Mizushina, Yoshiyuki; Sakaguchi, Kengo; Sugawara, Fumio; Ikekita, Masahiko; Kobayashi, Susumu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4162 - 4172
反应条件
1: NaNO2, aq. HCl 2: Ambient temperature View Scheme
参考文献
Kuramochi, Kouji; Sunoki, Takashi; Tsubaki, Kazunori; Mizushina, Yoshiyuki; Sakaguchi, Kengo; Sugawara, Fumio; Ikekita, Masahiko; Kobayashi, Susumu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4162 - 4172
反应条件
sodium hydrogencarbonate in methanol; water T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Kuramochi, Kouji; Sunoki, Takashi; Tsubaki, Kazunori; Mizushina, Yoshiyuki; Sakaguchi, Kengo; Sugawara, Fumio; Ikekita, Masahiko; Kobayashi, Susumu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4162 - 4172
反应条件
sodium hydrogencarbonate in methanol; water T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Kuramochi, Kouji; Sunoki, Takashi; Tsubaki, Kazunori; Mizushina, Yoshiyuki; Sakaguchi, Kengo; Sugawara, Fumio; Ikekita, Masahiko; Kobayashi, Susumu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4162 - 4172
