2-(4-氟苯酰基)苯甲酸合成路线 （共 12 条）
反应条件
AlCl3, aluminium chloride T=20°C; Friedel-Crafts Acylation; Heating;
参考文献
Chamoli, Tanu; Rawat; Jacob, Melissa
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 5 p. 748 - 757
反应条件
1: in tetrahydrofuran T=30°C; 1 h; 2: With hydrogenchloride in water; toluene T=35°C; 1 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/24630 A1, 2006 ;
Location in patent: Page/Page column 5; 6 ;
反应条件
hydrogenchloride; aluminium chloride in o-di-fluorobenzene; hexane; benzene
参考文献
Janssen Pharmaceutica N.V.
Patent: US4766125 A1, 1988 ;
反应条件
palladium (II) trifluoroacetate; silver carbonate in ethylene glycol dimethyl ether T=150°C; 24 h; Sealed tube; chemoselective reaction;
参考文献
Miao, Jinmin; Ge, Haibo
Organic Letters, 2013 , vol. 15, # 12 p. 2930 - 2933
参考文献
Chamoli, Tanu; Rawat; Jacob, Melissa
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 5 p. 748 - 757
参考文献
Hahn; Reid
Journal of the American Chemical Society, 1924 , vol. 46, p. 1647
反应条件
1: (i) SOCl2, (ii) /BRN= 102549/ 2: LiAlH4 3: CrO3, aq. AcOH View Scheme
参考文献
Coombs,R. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 1072 - 1074
反应条件
1: H2SO4 2: NH3 3: Br2, aq. KOH View Scheme
参考文献
Suzuki,K. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2239 - 2242
反应条件
hydrogen; palladium on activated charcoal in methanol T=70°C; P=15200 Torr; 12 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2006/24630 A1, 2006 ;
Location in patent: Page/Page column 6 ;
反应条件
zinc(II) chloride T=115 - 120°C; 8 h;
参考文献
Gronowska, J.; Kalinowska, A.
Journal of Fluorine Chemistry, 1993 , vol. 61, # 3 p. 233 - 238
