(2-氧代-2-苯乙基)-氨基甲酸叔丁酯合成路线 （共 10 条）
反应条件
1: 86 percent / HCO2H; Et3N; (R,R)-N-tosyl-1,2-diphenylethylenediamine / [Ru(cymene)Cl2]2 2: 27 percent / TFA / CH2Cl2 View Scheme
参考文献
Kawamoto, Aparecida; Wills, Martin
Tetrahedron Asymmetry, 2000 , vol. 11, # 16 p. 3257 - 3261
反应条件
1: 1) NaH / 1) DMF, NaH, 0 deg C, 0.25 h, 2) DMF, 0 deg C, 1 h 2: 78 percent / conc. HCl / methanol / 1 h / Heating View Scheme
参考文献
Guzman; Quintero; Muchowski
Canadian Journal of Chemistry, 1991 , vol. 69, # 12 p. 2059 - 2063
反应条件
1: 88 percent / aq. NaHCO3 / ethanol / 144 h / 20 °C 2: 86 percent / HCl / dioxane / 0.42 h / 20 °C View Scheme
参考文献
Myers, Michael C.; Wang, JinLing; Iera, Jaclyn A.; Bang, Jeong-Kyu; Saito, Shin'ichi; Hara, Toshiaki; Zambetti, Gerard P.; Appella, Daniel H.
Journal of the American Chemical Society, 2005 , vol. 127, # 17 p. 6152 - 6153
反应条件
sodium hydrogencarbonate in ethanol
T=20°C; 48 h;
参考文献
Gilmore, Nathan J.; Jones, Simon; Muldowney, Mark P.
Organic Letters, 2004 , vol. 6, # 16 p. 2805 - 2808
反应条件
isopropylmagnesium chloride in tetrahydrofuran
T=-15 - 20°C;
参考文献
Liu, Jinchu; Ikemoto, Norihiro; Petrillo, Daniel; Armstrong III, Joseph D.
Tetrahedron Letters, 2002 , vol. 43, # 46 p. 8223 - 8226
反应条件
in chloroform; water
参考文献
Nippon Soda Co., Ltd.
Patent: US6410749 B1, 2002 ;
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide
T=20°C; 21 h;
参考文献
Miyata, Sachiho; Kumamoto, Takuya; Ishikawa, Tsutomu
Helvetica Chimica Acta, 2007 , vol. 90, # 7 p. 1420 - 1438
反应条件
potassium carbonate in water; ethyl acetate
T=0 - 30°C; 3.5 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.; Fujifilm Corporation
Patent: EP1867640 A1, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1: acetophenone With lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Armstrong, Alan; Edmonds, Ian D.; Swarbrick, Martin E.; Treweeke, Nigel R.
Tetrahedron, 2005 , vol. 61, # 35 p. 8423 - 8442
反应条件
1: 91 percent / Et3N / CH2Cl2 / 1.3 h / 20 °C
2: 94 percent / pyridinium dichromate / dimethylformamide / 21 h / 20 °C
View Scheme
参考文献
Miyata, Sachiho; Kumamoto, Takuya; Ishikawa, Tsutomu
Helvetica Chimica Acta, 2007 , vol. 90, # 7 p. 1420 - 1438
