sodium hydroxide in 1,4-dioxane; ethanol 3 h; Ambient temperature;

1: 82 percent / 0.33 h / 100 °C 2: 85 percent / 1N aq. sodium hydroxide / dioxane; ethanol / 3 h / Ambient temperature View Scheme

1: tetrahydrofuran / 20 h / Ambient temperature 2: 4 N aq. NaOH / ethanol / 1 h View Scheme

1: 1.) sodium hydride / 1.) THF, room temperature, 2 h, 2.) THF, room temperature, 4 h 2: tetrahydrofuran / 20 h / Ambient temperature 3: 4 N aq. NaOH / ethanol / 1 h View Scheme