1: in dichloromethane T=38 - 40°C; 2: With hydrogenchloride in ethanol; isopropyl alcohol

1: in toluene T=25 - 30°C; 2: With sodium hydrogencarbonate in dichloromethane; water 3: With hydrogenchloride in methanol; isopropyl alcohol pH=1 - 2;

dicyclohexyl-carbodiimide in dichloromethane T=0 - 5°C; 1 h; Product distribution / selectivity;

1: (R/S)-tetrahydrofuran-2-carboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=40 - 45°C; 0.5 - 0.583333 h; 2: N1-methyl-N1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine in tetrahydrofuran 1.5 - 1.75 h; Heating / reflux; Product distribution / selectivity;

in dichloromethane T=0 - 5°C; 1 h; Product distribution / selectivity;

in tetrahydrofuran T=-20 - 65°C; Product distribution / selectivity;

triethylamine in dichloromethane 1.5 - 1.75 h; Product distribution / selectivity;

in dichloromethane T=-10 - -5°C; 1 h; Product distribution / selectivity;