2,2-二甲基-4-戊酸甲酯合成路线 （共 17 条）
反应条件
1: 91 percent / LiAlH4 / diethyl ether / 3 h / Heating 2: 76 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.5 h / -78 °C View Scheme
参考文献
Chen, Guanghui; Ma, Xun S.; Guan, Zhibin
Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6697 - 6704
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; 4 h; Reflux;
参考文献
Brimioulle, Richard; Guo, Hao; Bach, Thorsten
Chemistry - A European Journal, 2012 , vol. 18, # 24 p. 7552 - 7560
反应条件
sodium hydroxide in methanol; water T=80°C;
参考文献
Crimmins, Michael T.; Carroll, Charlotte A.; Wells, Angela J.
Tetrahedron Letters, 1998 , vol. 39, # 39 p. 7005 - 7008
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C; 2.5 h;
参考文献
Crimmins, Michael T.; Carroll, Charlotte A.; Wells, Angela J.
Tetrahedron Letters, 1998 , vol. 39, # 39 p. 7005 - 7008
反应条件
methanol in hexane
T=0°C;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/91674 A1, 2006 ;
Location in patent: Page/Page column 99 ;
WO 2006/091674 A1
反应条件
1: 2-methylpropanoic acid methyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 1.66667 h;
2: allyl bromide in tetrahydrofuran; hexane
T=-78°C; 1 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/108701 A1, 2006 ;
Location in patent: Page/Page column 57 ;
WO 2006/108701 A1
反应条件
sulfuric acid in methanol; toluene
参考文献
Wang, Lin; Arthur, Samuel David; McCord, Elizabeth Forrester; Wang, Yueli; Morken, Peter Arnold; Johnson, Lynda Kaye
Patent: US2003/212225 A1, 2003 ;
反应条件
1: methyl 2-dimethylbismuthanyl-2-methylpropanoate With tBu4ZnLi2 in tetrahydrofuran
T=-78°C; 0.5 h;
2: 3-iodoprop-1-ene in tetrahydrofuran
T=-78 - 20°C; 3 h;
参考文献
Kayahara, Eiichi; Yamada, Hiroto; Yamago, Shigeru
Chemistry - A European Journal, 2011 , vol. 17, # 19 p. 5272 - 5280
反应条件
in hexane; dichloromethane
0.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2007/67615 A2, 2007 ;
Location in patent: Page/Page column 98 ;
WO 2007/067615 A2
参考文献
Maillard, Bernard; Kharrat, Abdelmajid; Rakotomanana, Felicien; Montaudon, Evelyne; Gardrat, Christian
Tetrahedron, 1985 , vol. 41, # 19 p. 4047 - 4056
