3-甲基-3-丁烯-1-醇合成路线 （共 220 条）
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride
1.) water; Yield given. Multistep reaction;
参考文献
Sydnes, Leiv K.; Skare, Soelvi
Canadian Journal of Chemistry, 1984 , vol. 62, p. 2073 - 2078
反应条件
1: 1.) dicyclohexylcarbodiimide, cuprous chloride / 1.) 5h, 60 deg C, 2.) 12h, 100 deg C
2: trifluoroacetic acid / 1.) 3 days, room temperature, 2.) EtOH, K2CO3, 15 h
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
反应条件
dimethylaluminum chloride in dichloromethane
T=25°C; 1 h;
参考文献
Snider; Rodini; Kirk; Cordova
Journal of the American Chemical Society, 1982 , vol. 104, # 2 p. 555 - 563
参考文献
Du Pont de Nemours and Co.
Patent: US2789996 , 1953 ;
反应条件
Title compound not separated from byproducts;
参考文献
Wilkes, John B.; Wall, Robert G.
Journal of Organic Chemistry, 1980 , vol. 45, # 2 p. 247 - 250
反应条件
chloro-trimethyl-silane; water; sodium iodide in acetonitrile
0.5 h; Ambient temperature;
参考文献
Kanai, Takaya; Irifune, Shinji; Ishii, Yasutaka; Ogawa, Masaya
Synthesis, 1989 , # 4 p. 283 - 286
反应条件
Amberlyst H15 in Petroleum ether
47 h; Ambient temperature;
参考文献
Ladlow, Mark; Pattenden, Gerald
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1107 - 1118
反应条件
1: 75 percent / Ph3P, NBS / CH2Cl2 / 3 h / Ambient temperature
2: 87 percent / Li2CuCl4 / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) 0 deg C, 6 h, 3.) room temperature, 18 h
View Scheme
参考文献
Berkowitz, William F.; Wu, Yanzhong
Journal of Organic Chemistry, 1997 , vol. 62, # 5 p. 1536 - 1539
反应条件
anhydrous magnesium perchlorate
T=20°C; 0.5 h;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Dalpozzo, Renato; Marcantoni, Enrico; Massaccesi, Massimo; Rinaldi, Samuele; Sambri, Letizia
Synlett, 2003 , # 1 p. 39 - 42
反应条件
triethylamine in dichloromethane
参考文献
Breuilles, Pascal; Uguen, Daniel
Bulletin de la Societe Chimique de France, 1988 , # 4 p. 705 - 720
