2-[(4-溴苯基)甲基]-1,3-苯并恶唑合成路线 （共 9 条）
反应条件
toluene-4-sulfonic acid in toluene
4 h; Reflux;
参考文献
Wisastra, Rosalina; Ghizzoni, Massimo; Boltjes, Andre; Haisma, Hidde J.; Dekker, Frank J.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5027 - 5032
反应条件
in N,N-dimethyl-formamide
T=60°C; 2 h;
参考文献
Fan, Xuesen; He, Yan; Zhang, Xinying; Guo, Shenghai; Wang, Yangyang
Tetrahedron, 2011 , vol. 67, # 34 p. 6369 - 6374
反应条件
1,4-diaza-bicyclo[2.2.2]octane in 1-methyl-pyrrolidin-2-one
T=100°C; 10 h;
参考文献
Tao, Kemei; Zheng, Jianlong; Liu, Zhaogui; Shen, Wang; Zhang, Jiancun
Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3246 - 3249
参考文献
Shin, Dong-Cheol; Kim, Hyung-Sun; Jeong, Sang-Yun; Jeong, Hyun-Ceol; Kim, Yun-Hi; Jung, Sung Ouk; Kwon, Soon-Ki
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2002 , vol. 377, p. 113 - 116
反应条件
in chloroform
6 h; Ambient temperature;
参考文献
Wagner; Eppner
Pharmazie, 1980 , vol. 35, # 5-6 p. 285 - 288
反应条件
1: 2) HCl(g) / 1) 1) dioxane, 2) dioxane, 0 deg C
2: 72 percent / CHCl3 / 6 h / Ambient temperature
View Scheme
参考文献
Wagner; Eppner
Pharmazie, 1980 , vol. 35, # 5-6 p. 285 - 288
反应条件
1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 1 h / 60 °C
2: N,N-dimethyl-formamide / 2 h / 60 °C
View Scheme
参考文献
Fan, Xuesen; He, Yan; Zhang, Xinying; Guo, Shenghai; Wang, Yangyang
Tetrahedron, 2011 , vol. 67, # 34 p. 6369 - 6374
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C
2: toluene-4-sulfonic acid / toluene / 4 h / Reflux
View Scheme
参考文献
Wisastra, Rosalina; Ghizzoni, Massimo; Boltjes, Andre; Haisma, Hidde J.; Dekker, Frank J.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5027 - 5032
反应条件
1: thionyl chloride / 0.5 h / 60 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: toluene-4-sulfonic acid / toluene / 4 h / Reflux
View Scheme
参考文献
Wisastra, Rosalina; Ghizzoni, Massimo; Boltjes, Andre; Haisma, Hidde J.; Dekker, Frank J.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 5027 - 5032
