pyridine 18 h; Ambient temperature;

1: 86 percent / manganese dioxide / CH2Cl2 / 3 h / Heating 2: 1.) acetic acid, Br2 / 2.) DMF, 70 deg C, 3 h 3: 16 h / 80 °C View Scheme

1: 67 percent / sodium methoxide / 18 h / Ambient temperature 2: 86 percent / manganese dioxide / CH2Cl2 / 3 h / Heating 3: 1.) acetic acid, Br2 / 2.) DMF, 70 deg C, 3 h 4: 16 h / 80 °C View Scheme

1: 1.) acetic acid, Br2 / 2.) DMF, 70 deg C, 3 h 2: 16 h / 80 °C View Scheme

T=80°C; 16 h;