外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺合成路线 （共 32 条）
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
2: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
3: 33 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 87 percent / triethylamine / CH2Cl2 / 12 h / 0 °C
2: HCl; H2 / Pd/C 10percent / ethanol / 12 h / 60 °C / 11015.3 Torr
3: triethylamine / acetone / Heating
4: 10percent H2SO4 / Heating
5: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
2: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
3: 74 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
2: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
3: 70 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
2: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
3: 80 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
2: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
3: 70 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
