外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺合成路线

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→376348-70-8N-叔丁氧羰基-(1S)-3-[3-(3-异丙基-5-甲基-4H-1,2,4-三唑-4-基)-外-8-氮杂双环[3.2.1]辛-8-基]-1-苯基-1-丙胺

参考文献

Asano, Shigehiro; Gavrilyuk, Julia; Burton, Dennis R.; Barbas, Carlos F.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 2 p. 133 - 137

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺+79-30-1异丁酰氯→376348-67-3N-((1R,3s,5S)-8-苄基-8-氮杂二环[3.2.1]辛烷-3-基)异丁酰胺

参考文献

CONCERT PHARMACEUTICALS INC.
Patent: WO2008/63600 A2, 2008 ;
Location in patent: Page/Page column 11-12; 26-27 ;
WO 2008/063600 A2

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺+513-36-0氯代异丁烷→376348-67-3N-((1R,3s,5S)-8-苄基-8-氮杂二环[3.2.1]辛烷-3-基)异丁酰胺

参考文献

Auspex Pharmaceuticals, Inc.
Patent: US2008/146605 A1, 2008 ;
Location in patent: Page/Page column 41 ;

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→423165-13-38-苄基-3-外型-(5-异丙基-3-甲基-4H-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷

参考文献

Asano, Shigehiro; Gavrilyuk, Julia; Burton, Dennis R.; Barbas, Carlos F.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 2 p. 133 - 137

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→132234-68-5exo-3-Boc-氨基托烷

参考文献

SHANGHAI TARGETDRUG CO., LTD.; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
Patent: US2011/251192 A1, 2011 ;
US 20110251192 A1

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→76351-84-32-氨基-N-[8-[(4-氯苯基)甲基]-8-氮杂双环[3.2.1]辛烷-3-基]-4-甲氧基嘧啶-5-甲酰胺

参考文献

Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→76351-85-4

参考文献

Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→76351-86-52-氨基-4-甲氧基-N-[8-[(4-甲基苯基)甲基]-8-氮杂双环[3.2.1]辛烷-3-基]嘧啶-5-甲酰胺

参考文献

Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110

1521-38-62,3-二甲氧基苯甲酸+76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺→76352-13-1曲帕必利

参考文献

Slowinski, Tomasz; Stefanowicz, Jacek; Dawidowski, MacIej; Kleps, Jerzy; Czuczwar, Stanislaw; Andres-Mach, Marta; Luszczki, Jarogniew J.; Nowak, Gabriel; Stachowicz, Katarzyna; Szewczyk, Bernadeta; Slawinska, Anna; Mazurek, Aleksander P.; Mazurek, Andrzej; Plucinski, Franciszek; Wolska, Irena; Herold, Franciszek
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4474 - 4488

76272-36-1外向-8-苄基-8-氮杂双环[3.2.1]辛-3-胺+72418-38-32-氨基-4-甲氧基-5-嘧啶羧酸→76352-24-42-氨基-4-甲氧基-N-[8-(苯基甲基)-8-氮杂双环[3.2.1]辛烷-3-基]嘧啶-5-甲酰胺

参考文献

Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110