内向-8-苄基-8-氮杂双环[3.2.1]辛烷-3-胺合成路线 （共 5 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol; acetic acid P=2316.8 Torr; 48 h;
参考文献
Bagley; Riley
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 3 p. 485 - 488
反应条件
1: 91 percent / Hydroxylamine hydrochloride, sodium bicarbonate / aq. ethanol / 0.5 h / 100 °C 2: 46 percent / Hydrogen / Platinum oxide / ethanol; acetic acid / 48 h / 2316.8 Torr View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 485 - 488
反应条件
1: 70 percent / NaN3 / ethanol; H2O / 20 h / Heating 2: 81 percent / LiAlH4 / diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 2 p. 105 - 110
反应条件
sodium in pentan-1-ol; toluene 0.25 h; RefluxInert atmosphere; Overall yield = 95 percent; Overall yield = 18 g;
参考文献
Organic Process Research and Development, , vol. 12, # 6 p. 1094 - 1103
反应条件
1: 1N aq. NaOH / 2-methyl-propan-2-ol / 3 h 2: H2 / 20percent Pd/C / methanol / 2585.7 Torr View Scheme
参考文献
Kiely, John S.; Hutt, Marland P.; Culbertson, Townley P.; Bucsh, Ruth A.; Worth, Donald F.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 656 - 663
