N-(叔丁氧羰基)苯丙氨酰甘氨酸甲酯合成路线 （共 4 条）
反应条件
methanol; sodium hydroxide T=20°C; 3 h;
参考文献
Zhang, Jian; Li, Xiaoyang; Jiang, Yuqi; Feng, Jinhong; Li, Xiaoguang; Zhang, Yingjie; Xu, Wenfang
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 11 p. 3055 - 3064
反应条件
1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C
2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C
2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
4: TFA, anisole / CH2Cl2 / 1 h / 0 °C
5: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C
2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
3: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
4: TFA, anisole / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
