1: 69 percent / K2CO3 / dimethylformamide / Ambient temperature 2: H2 / Raney Ni / H2O / 1.5 h / 760 Torr / Ambient temperature 3: Et3N / methanol / 72 h / -18 °C 4: aq. acid / 25 °C / pH 3.34, var. pH, temp. View Scheme

1: 70 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature 2: 61 percent / 0.1N HCl / H2O / 3.5 h / Ambient temperature 3: HCl / ethanol / 72 h / Ambient temperature View Scheme