(s)-(-)-2-羟基-3-苯基丙酸苄酯合成路线 （共 12 条）
反应条件
1: (S)-2-hydroxy-3-phenylpropionic acid With caesium carbonate in methanol; water deprotonation; pH=7; 2: benzyl bromide in N,N-dimethyl-formamide T=20°C; benzylation; 6 h; Further stages.;
参考文献
Shin; Lee; Jung; Yoon
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7667 - 7675
反应条件
hydrogenchloride; sodium hydrogencarbonate; sodium iodide in N,N-dimethyl-formamide
参考文献
US5268361 A1, ;
US 5268361 A
反应条件
toluene-4-sulfonic acid in benzene 3 h; Heating;
参考文献
Khumtaveeporn, Kanjai; Ullmann, Astrid; Matsumoto, Kazutsugu; Davis, Benjamin G.; Jones
Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 249 - 261
反应条件
sodium hydrogencarbonate in benzene
参考文献
EP396065 A1, ;
EP 0396065 A1
反应条件
diazobicycloundecane in acetonitrile 1.) RT, 2 d, 2.) reflux, 1 h;
参考文献
Journal of the American Chemical Society, , vol. 114, # 13 p. 5295 - 5303
参考文献
US4727060 A1, ;
US 4727060 A
反应条件
1: 60 percent / NaNO2, 0.5M H2SO4 / H2O / 24 h / Ambient temperature 2: 1) Cs2CO3 / 1) MeOH, water, 2) DMF, a) 2 h, ice-bath, b) r.t., overnight View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 11 - 14
反应条件
trifluoroacetic acid in methanol T=25°C; Resolution of racemate;
参考文献
Magnetic Resonance in Chemistry, , vol. 48, # 2 p. 111 - 116
反应条件
in tetrahydrofuran 48 h; Ambient temperature;
参考文献
Davies, John S.; Howe, Joanne; Breton, Murielle Le
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 12 p. 2335 - 2340
反应条件
1: water; sodium carbonate / 4 h / |Reflux 2: triethylamine / acetone / 16 h / |Reflux View Scheme
参考文献
ACS Chemical Neuroscience, , vol. 4, # 8 p. 1204 - 1216
