6-氨基甲基-(9ci)-3-吡啶羧酸合成路线 （共 6 条）
反应条件
lithium hydroxide in 1,4-dioxane
T=20°C; 5 h;
参考文献
Choong, Ingrid C.; Lew, Willard; Lee, Dennis; Pham, Phuongly; Burdett, Matthew T.; Lam, Joni W.; Wiesmann, Christian; Luong, Tinh N.; Fahr, Bruce; DeLano, Warren L.; McDowell, Robert S.; Allen, Darin A.; Erlanson, Daniel A.; Gordon, Eric M.; O'Brien, Tom
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5005 - 5022
反应条件
1: SO2Cl
2: 38 percent / N-bromosuccinimide; benzoyl peroxide; acetic acid / benzene / 9 h / Heating
3: 69 percent / sodium azide / dimethylformamide / 0.5 h / 70 °C
4: H2 / 10 percent Pd/C / ethanol / 0.33 h / 1034.3 Torr
5: 1 M LiOH / dioxane / 5 h / 20 °C
View Scheme
参考文献
Choong, Ingrid C.; Lew, Willard; Lee, Dennis; Pham, Phuongly; Burdett, Matthew T.; Lam, Joni W.; Wiesmann, Christian; Luong, Tinh N.; Fahr, Bruce; DeLano, Warren L.; McDowell, Robert S.; Allen, Darin A.; Erlanson, Daniel A.; Gordon, Eric M.; O'Brien, Tom
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5005 - 5022
反应条件
1: 38 percent / N-bromosuccinimide; benzoyl peroxide; acetic acid / benzene / 9 h / Heating
2: 69 percent / sodium azide / dimethylformamide / 0.5 h / 70 °C
3: H2 / 10 percent Pd/C / ethanol / 0.33 h / 1034.3 Torr
4: 1 M LiOH / dioxane / 5 h / 20 °C
View Scheme
参考文献
Choong, Ingrid C.; Lew, Willard; Lee, Dennis; Pham, Phuongly; Burdett, Matthew T.; Lam, Joni W.; Wiesmann, Christian; Luong, Tinh N.; Fahr, Bruce; DeLano, Warren L.; McDowell, Robert S.; Allen, Darin A.; Erlanson, Daniel A.; Gordon, Eric M.; O'Brien, Tom
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5005 - 5022
反应条件
1: 69 percent / sodium azide / dimethylformamide / 0.5 h / 70 °C
2: H2 / 10 percent Pd/C / ethanol / 0.33 h / 1034.3 Torr
3: 1 M LiOH / dioxane / 5 h / 20 °C
View Scheme
参考文献
Choong, Ingrid C.; Lew, Willard; Lee, Dennis; Pham, Phuongly; Burdett, Matthew T.; Lam, Joni W.; Wiesmann, Christian; Luong, Tinh N.; Fahr, Bruce; DeLano, Warren L.; McDowell, Robert S.; Allen, Darin A.; Erlanson, Daniel A.; Gordon, Eric M.; O'Brien, Tom
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5005 - 5022
反应条件
1: H2 / 10 percent Pd/C / ethanol / 0.33 h / 1034.3 Torr
2: 1 M LiOH / dioxane / 5 h / 20 °C
View Scheme
参考文献
Choong, Ingrid C.; Lew, Willard; Lee, Dennis; Pham, Phuongly; Burdett, Matthew T.; Lam, Joni W.; Wiesmann, Christian; Luong, Tinh N.; Fahr, Bruce; DeLano, Warren L.; McDowell, Robert S.; Allen, Darin A.; Erlanson, Daniel A.; Gordon, Eric M.; O'Brien, Tom
Journal of Medicinal Chemistry, 2002 , vol. 45, # 23 p. 5005 - 5022
反应条件
1: H2, conc. HCl / 5 percent Pd-C / methanol / 10 h / Ambient temperature
2: 4 N NaOH / 2 h / Heating
View Scheme
参考文献
Isoda, Sumiro; Yamaguchi, Hitoshi; Satoh, Yoshinari; Miki, Tosaku; Hirata, Miyoshi
Chemical & Pharmaceutical Bulletin, 1980 , vol. 28, # 5 p. 1408 - 1414
