4,5-二氟-1,2-苯二胺合成路线 （共 13 条）
反应条件
hydrogenchloride; tin(ll) chloride
参考文献
Baudy, Reinhardt B.; Greenblatt, Lynne P.; Jirkovsky, Ivo L.; Conklin, Mary; Russo, Ralph J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 331 - 342
反应条件
palladium monocarbide in ethanol
参考文献
US2003/83315 A1, ;
US 20030083315 A1
反应条件
hydrogenchloride in methanol
参考文献
The Regents of the University of Michigan
Patent: US5360795 A1, 1994 ;
反应条件
1: 82 percent / HNO3, H2SO4 / 1 h / 5 - 10 °C 2: 70 percent / HCl / ethanol / 2 h / Heating 3: 42 percent / SnCl2.2H2O / HCl / 2 h / 50 - 60 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 6 p. 1517 - 1523
反应条件
1: 70 percent / HCl / ethanol / 2 h / Heating 2: 42 percent / SnCl2.2H2O / HCl / 2 h / 50 - 60 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 6 p. 1517 - 1523
反应条件
in isopropyl alcohol 16 h; Heating / reflux;
参考文献
US2008/119496 A1, ;
Page/Page column 9 ;
参考文献
Synthesis (Germany), , vol. 45, # 2 art. no. SS-2012-T0784-OP, p. 272 - 280
参考文献
New Journal of Chemistry, , vol. 30, # 5 p. 803 - 809
反应条件
1: 70 percent / ethanol / 1 h / Heating 2: 90 percent / POCl3 / 2 h / 120 °C View Scheme
参考文献
Piras, Sandra; Loriga, Mario; Paglietti, Giuseppe
Farmaco, 2004 , vol. 59, # 3 p. 185 - 194
反应条件
in tetrahydrofuran 72 h; Ambient temperature;
参考文献
Schwiebert, Kathryn E.; Chin, Donovan N.; MacDonald, John C.; Whitesides, George M.
Journal of the American Chemical Society, 1996 , vol. 118, # 17 p. 4018 - 4029
