3,5-二氯-2-羟基苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: potassium carbonate; methylethyl ketone 2: methanolic NaOH-solution View Scheme
参考文献
Claisen
Justus Liebigs Annalen der Chemie, 1919 , vol. 418, p. 102
反应条件
1: butanone; aqueous potassium carbonate; potassium iodide 2: aqueous methanol. KOH-solution 3: 230 °C View Scheme
参考文献
Tarbell; Wystrach
Journal of the American Chemical Society, 1943 , vol. 65, p. 2149,2151
反应条件
sulfuric acid
10 h; Reflux;
参考文献
Institute Of Medicinal Molecular Design, Inc.; ShionogiandCo., Ltd.
Patent: EP2208728 A1, 2010 ;
Location in patent: Page/Page column 48 ;
参考文献
Ginsburg
Journal of the American Chemical Society, 1951 , vol. 73, p. 2723
反应条件
chlorine; acetic acid
参考文献
Claisen
Justus Liebigs Annalen der Chemie, 1919 , vol. 418, p. 102
参考文献
Smith
Chemische Berichte, 1878 , vol. 11, p. 1225
反应条件
1: concentrated sulfuric acid / bei der Destillation
2: chlorine
View Scheme
参考文献
Cahours
Annales de Chimie (Cachan, France), 1844 , vol. <3> 10, p. 329,336, 353
Justus Liebigs Annalen der Chemie, 1843 , vol. 48, p. 65
参考文献
Cahours
Annales de Chimie (Cachan, France), 1844 , vol. <3> 10, p. 329,336, 353
Justus Liebigs Annalen der Chemie, 1843 , vol. 48, p. 65
参考文献
Tarbell; Wilson
Journal of the American Chemical Society, 1942 , vol. 64, p. 607,611
参考文献
Anschuetz,R.; Mehring
Justus Liebigs Annalen der Chemie, 1906 , vol. 346, p. 302
