2-羟基-3-溴-5-三氟甲基吡啶合成路线 （共 4 条）
反应条件
1: With bromine; sodium acetate in acetic acid T=20 - 80°C; 2.5 h; 2: With sodium hydrogencarbonate in water pH=8;
参考文献
Xue, Chu-Biao; Zheng, Changsheng; Cao, Ganfeng; Feng, Hao; Xia, Michael; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W.
Patent: US2005/267146 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;
US 20050267146 A1
反应条件
1: With trichlorophosphate T=100°C; 5 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2007/73934 A1, 2007 ;
Location in patent: Page/Page column 75 ;
反应条件
1: 3-Bromo-5-(trifluoromethyl)pyridin-2-ol With tert.-butyl lithium; sodium hydride in tetrahydrofuran; pentane T=-78 - 20°C; 0.333333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; pentane T=-50 - 20°C; 3: With water; sodium hydrogencarbonate; ammonium chloride more than 3 stages;
参考文献
Xue, Chu-Biao; Zheng, Changsheng; Cao, Ganfeng; Feng, Hao; Xia, Michael; Anand, Rajan; Glenn, Joseph; Metcalf, Brian W.
Patent: US2005/267146 A1, 2005 ;
Location in patent: Page/Page column 23 ;
US 20050267146 A1
反应条件
1: With sodium hydride in tetrahydrofuran T=-78°C; 0.0833333 h; 2: With tert.-butyl lithium; N,N-dimethyl-formamide in tetrahydrofuran T=-50°C; 10 h; 3: With hydrogenchloride in tetrahydrofuran; water T=20°C;
参考文献
Goble, Stephen D.; Yang, Lihu; Zhou, Changyou; Kothandaraman, Shankaran; Guiadeen, Deodialsingh; Butora, Gabor; Pastemak, Alexander; Mills, Sander G.
Patent: US2007/117797 A1, 2007 ;
Location in patent: Page/Page column 23 ;
US 20070117797 A1
