4-(4-乙氧基苯基)哌啶盐酸盐合成路线 （共 5 条）
反应条件
platinum(IV) oxide; hydrogen; acetic acid
T=20°C; P=2250.23 Torr; 9 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; LEHMANN-LINTZ, Thorsten; NOSSE, Bernd
Patent: WO2013/79668 A1, 2013 ;
Location in patent: Page/Page column 75 ;
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / methanol; 1,4-dioxane / 48 h / |Inert atmosphere; |Reflux
2: hydrogen; platinum(IV) oxide; acetic acid / 9 h / 20 °C / 2250.23 Torr
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; LEHMANN-LINTZ, Thorsten; NOSSE, Bernd
Patent: WO2013/79668 A1, 2013 ;
反应条件
1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / methanol; 1,4-dioxane / 48 h / |Inert atmosphere; |Reflux
2: hydrogen; platinum(IV) oxide; acetic acid / 9 h / 20 °C / 2250.23 Torr
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; LEHMANN-LINTZ, Thorsten; NOSSE, Bernd
Patent: WO2013/79668 A1, 2013 ;
反应条件
1.1: magnesium; iodine / tetrahydrofuran / 1 h / |Reflux
1.2: 0.83 h / 20 °C / |Reflux
1.3: 3 h / |Reflux
2.1: 5 palladium on charcoal; hydrogen / methanol / 24 h / 20 °C / 2947.82 Torr
View Scheme
参考文献
Arnatt, Christopher K.; Zaidi, Saheem A.; Zhang, Zhu; Li, Guo; Richardson, Amanda C.; Ware, Joy L.; Zhang, Yan
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 647 - 658
反应条件
1.1: magnesium; iodine / tetrahydrofuran / 1 h / |Reflux
1.2: 0.83 h / 20 °C / |Reflux
1.3: 3 h / |Reflux
2.1: 5 palladium on charcoal; hydrogen / methanol / 24 h / 20 °C / 2947.82 Torr
View Scheme
参考文献
Arnatt, Christopher K.; Zaidi, Saheem A.; Zhang, Zhu; Li, Guo; Richardson, Amanda C.; Ware, Joy L.; Zhang, Yan
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 647 - 658
