3-甲氧基-2-甲基-1H-吡啶-4-酮合成路线 （共 11 条）
反应条件
ammonium hydroxide T=70°C;
参考文献
Ma, Yongmin; Luo, Wei; Quinn, Peter J.; Liu, Zudong; Hider, Robert C.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6349 - 6362
反应条件
1: 74 percent / aq. KOH / cooling 2: 95 percent / aq. NH3 / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6349 - 6362
反应条件
trichlorophosphate T=90°C; 18 h;
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 4: 4 h / 100 °C 5: 2 M NaOH / 1 h / 100 °C 6: 100 percent / SOCl2 / CH2Cl2 / 2 h View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 4: 4 h / 100 °C 5: 2 M NaOH / 1 h / 100 °C View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 3: 91 percent / NaOMe / 18 h 4: 2 h / 90 °C 5: 2 N aq. NaOH / 2 h / 80 °C 6: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 7: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 3: 91 percent / NaOMe / 18 h 4: 2 h / 90 °C 5: 2 N aq. NaOH / 2 h / 80 °C 6: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 7: 2 N aq. NaOH / ethanol / 2 h / 50 °C 8: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C View Scheme
参考文献
Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 9 p. 2808 - 2811
反应条件
hydrogen bromide T=140 - 150°C; 4 h;
参考文献
Hwang; Proctor; Driscoll
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 9 p. 1074 - 1076
