4-氧代-4-(3-吡啶基)丁醛合成路线 （共 13 条）
反应条件
1.1: molecular sieves 4 Angstroem / CH2Cl2 / 16 h / 20 °C 1.2: 45 percent / NaCNBH3 / methanol; acetic acid / 16 h / 0 - 20 °C 2.1: 95 percent / aq. HCl; methanol View Scheme
参考文献
Loh, Teck-Peng; Zhou, Jian-Rong; Li, Xu-Ran; Sim, Keng-Yeow
Tetrahedron Letters, 1999 , vol. 40, # 44 p. 7847 - 7850
反应条件
ammonium acetate in ethanol Paal-Knoor reaction;
参考文献
Vega, Ismael El Drubi; Gale, Philip A.; Light, Mark E.; Loeb, Stephen J.
Chemical Communications, 2005 , # 39 p. 4913 - 4915
反应条件
in methanol; dichloromethane T=20°C; 1 h;
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
1: 1.) NH3, 2.) NH4Cl / 1.) MeOH, 4 deg C, 30 min, 2.) H2O, MeOH, RT, 24 h 2: 69 percent / 10percent aq. KOH / 24 h / Heating 3: 67 percent / H2 / 10percent Pd/C / aq. ethanol / 2 h / 760 Torr View Scheme
参考文献
Abbaspour, Aziz; Hecht, Stephen S.; Hoffmann, Dietrich
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3474 - 3477
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran; dichloromethane T=-78 - 20°C; 2: With Amberlyst 15 in tetrahydrofuran; dichloromethane T=20°C; 1 h; 3: With triethylamine in dichloromethane T=20°C; 1 h;
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
oxalic acid
T=90°C; 2 h;
参考文献
Abbaspour, Aziz; Hecht, Stephen S.; Hoffmann, Dietrich
Journal of Organic Chemistry, 1987 , vol. 52, # 15 p. 3474 - 3477
反应条件
1: With Amberlyst 15; water in acetone
T=20°C; 4 h;
2: With triethylamine in dichloromethane
T=20°C; 2 h;
参考文献
Baxendale, Ian R.; Brusotti, Gloria; Matsuoka, Masato; Ley, Steven V.
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 143 - 154
反应条件
oxalyl dichloride; triethylamine in dimethyl sulfoxide
Oxidation; Swern oxidation;
参考文献
Loh, Teck-Peng; Zhou, Jian-Rong; Li, Xu-Ran; Sim, Keng-Yeow
Tetrahedron Letters, 1999 , vol. 40, # 44 p. 7847 - 7850
反应条件
1.1: Mg / tetrahydrofuran / 1 h / 20 °C
1.2: Amberlite IRC-50 / tetrahydrofuran
2.1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Vega, Ismael El Drubi; Gale, Philip A.; Light, Mark E.; Loeb, Stephen J.
Chemical Communications, 2005 , # 39 p. 4913 - 4915
反应条件
1.1: 54 percent / DCC; Et3N / CH2Cl2 / 0 - 20 °C
2.1: Mg / tetrahydrofuran / 1 h / 20 °C
2.2: Amberlite IRC-50 / tetrahydrofuran
3.1: 73 percent / Amberlyst 15; Et3N / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Vega, Ismael El Drubi; Gale, Philip A.; Light, Mark E.; Loeb, Stephen J.
Chemical Communications, 2005 , # 39 p. 4913 - 4915
