7-氯-1H-吡唑并[3,4-c]吡啶合成路线 （共 10 条）
反应条件
1: 2.1 g / toluene / 2 h / 100 °C 2: 1.) phosphorus pentaoxide, potassium acetate, nitrosyl chloride, 2.) sodium carbonate / 1.) acetic acid, 2.) benzene, reflux View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
1: With potassium acetate; acetic anhydride; isopentyl nitrite in benzene 8 h; Heating; 2: With ammonia in methanol
参考文献
Kourafalos, Vassilios N.; Marakos, Panagiotis; Pouli, Nicole; Terzis, Aris; Townsend, Leroy B.
Heterocycles, 2002 , vol. 57, # 12 p. 2335 - 2343
反应条件
hydrogenchloride; chlorine 0.333333 h;
参考文献
Chapman, David; Hurst, Jim
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2398 - 2404
反应条件
1: tin(II) chloride, conc. hydrochloric acid / diethyl ether / 3 h / 100 °C 2: 2.1 g / toluene / 2 h / 100 °C 3: 1.) phosphorus pentaoxide, potassium acetate, nitrosyl chloride, 2.) sodium carbonate / 1.) acetic acid, 2.) benzene, reflux View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
1: 54 percent / toluene / 2 h / 100 °C 3: 67 percent / phosphorus pentasulphide / pyridine / 4.5 h / Heating 4: 71 percent / chlorine, conc. hydrochloric acid / 0.33 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
2: 67 percent / phosphorus pentasulphide / pyridine / 4.5 h / Heating 3: 71 percent / chlorine, conc. hydrochloric acid / 0.33 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
1: 67 percent / phosphorus pentasulphide / pyridine / 4.5 h / Heating 2: 71 percent / chlorine, conc. hydrochloric acid / 0.33 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
1: hydrochloric acid 2: 67 percent / phosphorus pentasulphide / pyridine / 4.5 h / Heating 3: 71 percent / chlorine, conc. hydrochloric acid / 0.33 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
P2O5; potassium acetate; sodium carbonate; nitrosyl chloride 1.) acetic acid, 2.) benzene, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2398 - 2404
反应条件
1: 7-chloro-1H-pyrazololt;3,4-cgt;pyridine With sodium hydride in tetrahydrofuran T=0°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Zhang, Yan; Ye, Wei; Wang, Haisheng; Schneller, Stewart W.
Synthesis, 2012 , vol. 44, # 5 p. 723 - 730
