3-氧代-1-哌嗪羧酸叔丁酯合成路线 （共 24 条）
反应条件
1: tetraphosphorus decasulfide / tetrahydrofuran / 12 h / 60 °C 2: dichloromethane / 12 h / 25 °C 3: ethanol / 12 h / |Reflux View Scheme
参考文献
Boehringer Ingelheim International GmbH; BYLOCK, Lars Anders
Patent: US2013/236468 A1, 2013 ;
反应条件
1: 1-tert-Butoxycarbonyl-3-oxopiperazine With sodium hydride in tetrahydrofuran
T=0°C; 1.75 h; Inert atmosphere;
2: benzyl bromide in tetrahydrofuran
T=20°C; 18 h; Inert atmosphere;
参考文献
Roche Palo Alto LLC
Patent: US2009/209553 A1, 2009 ;
Location in patent: Page/Page column 14-15 ;
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 4.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2006/14944 A1, 2006 ;
Location in patent: Page/Page column 29-30 ;
WO 2006/014944 A1
参考文献
Cumming; Le; Babu; Carroll; Chen; Favreau; Gaspari; Guo; Hobbs; Huang; Iserloh; Kennedy; Kuvelkar; Li; Lowrie; McHugh; Ozgur; Pan; Parker; Saionz; Stamford; Strickland; Tadesse; Voigt; Wang; Wu; Zhang
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3236 - 3241
