3-氧代-1-哌嗪羧酸叔丁酯合成路线 （共 24 条）
反应条件
tin(IV) chloride in 1,3,5-trimethyl-benzene Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/158394 A1, 2009 ;
Location in patent: Page/Page column 69; 71 ;
反应条件
in N,N-dimethyl-formamide; isopropyl alcohol
参考文献
Zeneca Limited
Patent: US6069145 A1, 2000 ;
反应条件
1: 1-tert-Butoxycarbonyl-3-oxopiperazine With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.416667 h; 2: ethyl iodide in N,N-dimethyl-formamide T=40°C; 15 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 72 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C;
参考文献
Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Melchiorre, Michele; Norcini, Monica; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, Maria Novella
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1431 - 1443
参考文献
Cumming; Le; Babu; Carroll; Chen; Favreau; Gaspari; Guo; Hobbs; Huang; Iserloh; Kennedy; Kuvelkar; Li; Lowrie; McHugh; Ozgur; Pan; Parker; Saionz; Stamford; Strickland; Tadesse; Voigt; Wang; Wu; Zhang
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3236 - 3241
反应条件
in Pestox XIV; 2,4-dimethylbutane; potassium tert-butylate; isopropyl alcohol
参考文献
Pharmacia and UpJohn Company
Patent: US6337329 B1, 2002 ;
Location in patent: Example 3 ;
反应条件
in 2,4-dimethylbutane; N,N-dimethyl-formamide; isopropyl alcohol
参考文献
FORD, CHARLES W.; WATTS, JEFFREY L.
Patent: US2002/9483 A1, 2002 ;
反应条件
in N,N-dimethyl-formamide; isopropyl alcohol
参考文献
Zeneca Limited
Patent: US6069145 A1, 2000 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 - 65 °C / Inert atmosphere 1.2: 2.5 h / 20 - 65 °C 2.1: sodium hydroxide; water / methanol / 2.5 h 2.2: pH 2 / Acidic conditions View Scheme
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan; GRIMWOOD, Mike; ZHU, Yongbao; DING, Yanbing
Patent: WO2011/26241 A1, 2011 ;
WO 2011/026241 A1
反应条件
lithium diisopropyl amide in tetrahydrofuran T=0°C;
参考文献
Kane, John M.; Carr, Albert A.
Tetrahedron Letters, 1980 , vol. 21, p. 3019 - 3020
