[7,7-二甲基-2-氧代双环[2.2.1]庚-1-基]甲烷磺酸合成路线 (共 13 条)
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 1 p. 43 - 46
反应条件
thionyl chloride; calcium carbonate
参考文献
Bunce,N.J.; Murray,N.G.
Tetrahedron, 1971 , vol. 27, p. 5323 - 5335
反应条件
1.1: potassium carbonate / water 1.2: 4 h / -60 °C / Inert atmosphere; Reflux 2.1: calcium chloride / anhydrous xylene / Darkness; Reflux; Inert atmosphere View Scheme
参考文献
Husar, Branislav; Moszner, Norbert; Lukac, Ivan
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 337 - 343
参考文献
Koell, Peter; Luetzen, Arne
Tetrahedron: Asymmetry, 1995 , vol. 6, # 1 p. 43 - 46
反应条件
trimethyl orthoformate in methanol
参考文献
Symyx Technologies, Inc.
Patent: US6316663 B1, 2001 ;
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US5136059 A1, 1992 ;
参考文献
SmithKline Beecham Corporation
Patent: US6335340 B1, 2002 ;
Location in patent: Example 23 ;
参考文献
Eisai Co., Ltd.
Patent: US4433159 A1, 1984 ;
反应条件
sulfuric acid; acetic anhydride
参考文献
Raza, Rabia; Saeed, Aamer; Lecka, Joanna; Sevigny, Jean; Iqbal, Jamshed
Medicinal Chemistry, 2012 , vol. 8, # 6 p. 1133 - 1139
反应条件
hydrogenchloride in ethanol; water; toluene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5180742 A1, 1993 ;